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Postinfectious Cough: A Promising Treatment with Zihua Wenfei Granules


Postinfectious cough is a bothersome condition that often develops after a respiratory tract infection. It can persist for a long time and significantly affect daily life. Unfortunately, the optimal treatment for this condition is still unknown. However, a new Chinese herbal prescription called Zihua Wenfei granule (ZHWFG) shows promise in the treatment of postinfectious cough. This article aims to explore the efficacy and safety of ZHWFG in managing postinfectious cough and provide an alternative option for its management.

Understanding Postinfectious Cough

Postinfectious cough is a common complication that occurs after a respiratory tract infection. It is characterized by a persistent cough that can last for weeks or even months. This lingering cough can be embarrassing, troublesome, and significantly impair daily life. The exact mechanisms behind postinfectious cough are not fully understood, but it is believed to be caused by inflammation and irritation of the airways.

The Need for Effective Treatment

Despite the prevalence and impact of postinfectious cough, there is a lack of consensus on the optimal treatment. Many over-the-counter cough remedies provide only temporary relief, and there is a need for a more effective and long-lasting solution. This is where Zihua Wenfei granules come into play.

Zihua Wenfei Granules: An Overview

Zihua Wenfei granules (ZHWFG) is a Chinese herbal prescription specifically formulated to treat postinfectious cough with wind-cold invading lungs syndrome. It is a combination of various traditional Chinese herbs known for their therapeutic properties in respiratory conditions. ZHWFG aims to alleviate cough symptoms, reduce inflammation, and restore the balance of the respiratory system.

The Research Study

A prospective, multi-center, randomized, double-blinded, placebo-controlled trial was conducted to investigate the efficacy and safety of ZHWFG in the treatment of postinfectious cough. The study enrolled 216 adult participants with postinfectious cough from six study centers across China. The participants were randomly assigned to one of three treatment groups.

  1. Group 1: Participants received 15 g of active ZHWFG three times daily.

  2. Group 2: Participants received 10 g of active ZHWFG plus 5 g of ZHWFG-matched placebo three times daily.

  3. Group 3: Participants received 15 g of ZHWFG-matched placebo three times daily.

The treatment duration was 14 consecutive days. The primary outcomes measured were the cough resolution rate and cough relief rate. Secondary outcomes included the time to cough resolution, change in cough symptom score, and adverse events.

Efficacy of Zihua Wenfei Granules

The study aimed to assess the efficacy of ZHWFG in terms of cough resolution and relief rates. The primary outcomes were measured by evaluating the participants' cough symptoms and their improvement over time. The results showed that ZHWFG demonstrated a significant improvement in cough resolution and relief rates compared to the placebo group.

Time to Cough Resolution and Relief

In addition to the overall rates of cough resolution and relief, the study also assessed the time it took for participants to experience these improvements. The results indicated that ZHWFG led to a faster resolution of cough symptoms compared to the placebo group. This finding suggests that ZHWFG may expedite the recovery process and provide relief to individuals suffering from postinfectious cough.

Improvement in Cough Symptom Score

The study measured the change in cough symptom score from baseline to post-treatment. The cough symptom score was evaluated using standardized assessment tools. The results demonstrated a significant reduction in the cough symptom score in the ZHWFG treatment groups compared to the placebo group. This indicates that ZHWFG effectively alleviated the severity of cough symptoms.

Traditional Chinese Medicine Syndrome Score

In addition to Western medicine assessments, the study also evaluated the traditional Chinese medicine syndrome score. Traditional Chinese medicine takes into account the overall health and balance of the body. The results showed that ZHWFG led to a significant improvement in the traditional Chinese medicine syndrome score at days 7 and 14 of the treatment period. This suggests that ZHWFG not only targets the symptoms but also addresses the underlying imbalances in the body.

Safety of Zihua Wenfei Granules

Ensuring the safety of any treatment is crucial. The study assessed the safety of ZHWFG by monitoring and documenting any adverse events that occurred during the treatment period. Fortunately, no serious adverse events were reported, indicating that ZHWFG is well-tolerated and safe for use in managing postinfectious cough.


Postinfectious cough can be a persistent and bothersome condition, but the optimal treatment has remained elusive. The research study on Zihua Wenfei granules (ZHWFG) provides promising results in the management of postinfectious cough. The efficacy of ZHWFG in terms of cough resolution, relief rates, and improvement in cough symptom scores supports its potential as an effective treatment option. Additionally, the safety profile of ZHWFG further enhances its appeal as a natural alternative for managing postinfectious cough. With further research and validation, ZHWFG may become a valuable addition to the treatment options available for individuals suffering from this condition.

Additional Information:

  • ZHWFG is a proprietary Chinese herbal prescription that combines multiple herbs known for their respiratory health benefits.

  • The trial registration number for the research study is ChiCTR1900022078.

  • The study aims to provide evidence for the efficacy of Chinese herbal medicine in the treatment of postinfectious cough.


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