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Transforming the Biopharmaceutical Landscape: Tonix Pharmaceuticals

Tonix Pharmaceuticals, a clinical-stage biopharmaceutical firm, has been at the forefront of breakthrough medical advancements, leveraging their expertise to alleviate human suffering through innovative therapeutics.

A Diverse Portfolio

Tonix's expansive portfolio includes product candidates within the central nervous system (CNS), rare disease, immunology, and infectious disease sectors.

Central Nervous System (CNS) Candidates

The CNS portfolio is a blend of small molecules and biologics, designed to treat a variety of conditions, from neurologic and psychiatric to pain and addiction. Among these, TNX-102 SL, a sublingual tablet of cyclobenzaprine HCl, is undergoing mid-Phase 3 development for fibromyalgia treatment. The top-line data from this study is anticipated in the last quarter of 2023.

In addition, Tonix is also developing TNX-102 SL to tackle Long COVID, a persistent post-acute COVID-19 condition. The enrollment for Phase 2 of this study has concluded, with results expected in the third quarter of 2023.

Tonix continues to expand its CNS portfolio with TNX-1900 and TNX-601 ER. While TNX-1900 is being developed for chronic migraines, TNX-601 ER aims to treat major depressive disorder (MDD), with top-line results for both expected by 2024.

TNX-102 SL is Tonix's lead CNS candidate

Infectious Disease Pipeline

Tonix's pipeline for infectious diseases includes TNX-801, a vaccine designed to prevent smallpox and monkeypox. The Phase 1 study is expected to be initiated in the first quarter of 2024. TNX-801 also serves as the live virus vaccine platform for other infectious diseases.

The infectious disease portfolio also includes TNX-3900 and TNX-4000, broad-spectrum small molecule oral antivirals.

Rare Disease and Immunology Portfolio

Tonix's rare disease portfolio features TNX-2900 for treating Prader-Willi syndrome. The FDA has granted Orphan Drug designation to TNX-2900.

In the realm of immunology, Tonix is developing biologics to address organ transplant rejection, autoimmunity, and cancer. TNX-1500 is a humanized monoclonal antibody targeting CD40-ligand (CD40L or CD154), developed for preventing allograft rejection and treating autoimmune diseases, with a Phase 1 study expected to begin in 2023.

Tonix's Future Prospects

In the coming years, Tonix aims to further expand its portfolio while continuing to develop innovative therapeutics. With a strong focus on treating rare diseases and conditions that severely affect the quality of life, Tonix's mission is to alleviate human suffering and provide an improved life for those affected.

As new trials are expected to commence, the future looks promising for Tonix Pharmaceuticals, and their commitment to developing groundbreaking therapeutics is evident in their robust portfolio. With a focus on diseases that lack sufficient treatment options, Tonix is paving the way for future advancements in the pharmaceutical industry.


Tonix Pharmaceuticals is continuing to make strides in the biopharmaceutical sector. With a diverse portfolio and a dedication to alleviating human suffering, Tonix’s work is a beacon of hope for the countless individuals who suffer from rare diseases, mental health disorders, and infectious diseases.

"Innovation is the calling card of the future." - Anna Eshoo
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